Physical properties of a molecular entity can vary greatly depending on the solid form (salt, cocrystal, amorphous dispersion or crystalline polymorph). By screening and selecting solid forms early in development, we provide the basis for consistent production and performance while reducing costs associated with toxicological bridging studies or further process development efforts. Optimization of available solid forms provides an opportunity to overcome physical property challenges or potential form control issues by identifying more promising alternatives.

We provide a complete suite of solid-form screening services to select the most appropriate solid forms for intermediates and drug substances. Sensitive to the different requirements of drug indication, stage of development, intended formulation and storage conditions, our experts customize investigations to identify the most appropriate forms for desired physical properties and controlled scale-up.