AMRI’s drug metabolism and pharmacokinetics (DMPK) group delivers expert solutions for your drug discovery programs. We provide in vitro DMPK and bioanalytical/pharmacokinetic services that span all stages of drug discovery, including exploratory, hit-to-lead, lead optimization and candidate selection, as well as the preclinical IND-enabling studies. Our scientific expertise includes biochemistry, enzymology, pharmacokinetics, analytical chemistry, mass spectrometry, cell biology, pharmacology and toxicology.
Our experienced team brings strong problem-solving skills and expertise in a large variety of assays and techniques used to assess drug absorption, distribution, metabolism and excretion (ADME) in vitro. We deliver high-quality data that identifies DMPK liabilities and guides the structure property relationships (SPRs) of your project compounds.
Our complete suite of services includes:
- Comprehensive set of high-quality in vitro ADMET and DMPK studies to help you initiate and complete your IND-enabling programs
- Drug metabolite ID and synthesis
- Convenient AMRI Express Ordering Portal