October 3, 2018
- Blood plasma from desired species.
- Stability determined by measuring percent remaining of test compound at multiple time points during incubation in plasma.
|Test Compound Concentration||10 µM|
|Percent Organic Solvent in Incubation||0.5% acetonitrile|
|Incubation Time||0, 15, 30, 60, and 90 minutes|
|Positive Control||Propantheline and/or Enalapril|
|Analysis||LC-MS (LC-MS/MS if necessary)|
|Number of Repeats||2|
Deliverable: Half-life of test compound.
Test Compound Requirement: 1-2 mg dry powder or 100-200 µL of 10 mM DMSO stock solution.