October 3, 2018
- Fresh whole blood from desired species.
- Human blood is mixed gender. All other species are male.
- Stability determined by measuring percent remaining of test compound at multiple time points during incubation in blood.
|Test Compound Concentration||1 µM|
|Percent Organic Solvent in Incubation||0.5% acetonitrile|
|Incubation Time||0, 15, 30, 60, and 90 minutes|
|Analysis||LC-MS (LC-MS/MS if necessary)|
|Number of Repeats||2|
Deliverable: Half-life of test compound.
Test Compound Requirement: 1-2 mg dry powder or 100-200 µL of 10 mM DMSO stock solution.