- Agreement Includes Licensing Fee, Funded R&D, Milestone & Royalty Opportunities for Multiple Potential Products -
Albany, NY (October 24, 2005) -- Albany Molecular Research, Inc. (Nasdaq: AMRI) today announced a licensing agreement with Bristol-Myers Squibb (NYSE: BMY) for its broad program of compounds that encompass biogenic amine reuptake inhibitors in development for the treatment of depression and other central nervous system disorders.
Under the terms of the agreement, Bristol-Myers Squibb will receive an exclusive license to develop and commercialize multiple potential products from AMRI’s proprietary amine neurotransmitter reuptake inhibitors identified in one of AMRI’s proprietary research programs. AMRI is receiving an upfront payment of $8 million. Bristol-Myers Squibb will also provide approximately $10 million in research funding to AMRI over a three year period to further characterize existing compounds as well as identify additional compounds. In addition to the upfront payment and research funding, AMRI will be eligible to receive up to $66 million per compound in development and regulatory milestone payments for the first two compounds and additional milestone payments of up to $22 million per compound on subsequent compounds. Bristol-Myers Squibb will pay AMRI royalties on worldwide sales of commercialized compounds.
The agreement includes provisions for AMRI to potentially provide additional chemistry services, including manufacturing, should Bristol-Myers Squibb elect to outsource such activities.
The compounds identified to date encompass various combinations of amine-transporter inhibition profiles that act selectively or in combination to increase brain levels of serotonin, norepinephrine or dopamine. Triple reuptake inhibitors represent a new class of therapeutic agents which can potentially lead to an improved treatment for depression and/or other diseases of the central nervous system.
"We are thrilled to be working with Bristol-Myers Squibb on the further development of these compounds,” said AMRI Chairman, CEO and President Thomas E. D’Ambra, Ph.D. “We are excited by the commercial potential for these compounds and believe that ultimately there is a possibility that our combined efforts could yield multiple drugs with a range of different profiles as amine neurotransmitter reuptake inhibitors, useful for the treatment of several different CNS disease indications. This licensing agreement reflects the significant efforts put into the program by AMRI scientists. However, we recognize it is time to put this technology into the hands of a company that is better suited with the experience required to realize the significant commercial potential. Bristol-Myers Squibb is an ideal company for this technology, and we look forward to a productive and mutually rewarding collaboration.”
Albany Molecular Research, Inc. is a global drug discovery company that provides chemistry services to pharmaceutical and biotechnology companies and conducts its own proprietary R&D programs.